Psychedelics work mainly by interacting with serotonin receptors in your brain, especially one called 5-HT2A. When this happens, your brain’s usual communication highways get temporarily rewired. Parts of your brain that don’t normally talk to each other suddenly start having conversations, while the area responsible for your inner critic and sense of self quiets down a bit. Brain scans show these substances create new temporary connections between different regions, which is why people often report completely fresh perspectives on old problems. Psychedelics also seem to boost your brain’s natural ability to form new connections and pathways, which scientists call neuroplasticity. Additionally, they calm down the amygdala, your brain’s alarm system, while helping emotional and logical thinking areas work together better. This unique brain state creates special opportunities for learning and emotional healing when you have the right support.