Is Psychedelic Therapy Legal in Mexico?
Mexico currently offers a lawful pathway to supervised therapeutic use of at least one psychedelic.
Status by substance
Statuses reflect lawful access for supervised therapeutic use — not recreational legality. Last reviewed 2026-06.
Psilocybin
IllegalPsilocybin/psilocin are prohibited psychotropics under Article 245 of the General Health Law (Ley General de Salud). No regulated therapeutic pathway. Traditional/ceremonial indigenous use is tolerated and shielded under Federal Penal Code Article 195 bis; a 2021 SCJN amparo allowed limited personal therapeutic use, but there is no general lawful supervised-therapy program. Religious/cultural tolerance does not create green access.
Official source (2026-06) ↗MDMA
IllegalMDMA is a prohibited psychotropic under Article 245 of the General Health Law; no therapeutic pathway. Possession below an administrative threshold (~200 mg / pill, 50 mg powder) is not criminally prosecuted, but supply and supervised therapeutic use remain illegal.
Official source (2026-06) ↗Ibogaine
Legal / regulated accessUnscheduled — ibogaine is not listed in the General Health Law controlled-substances schedules. Licensed physicians/clinics administer it lawfully under COFEPRIS health-facility oversight; Mexico is the most-accessed destination for ibogaine treatment.
Official source (2026-06) ↗DMT / Ayahuasca
IllegalDMT (the active alkaloid in ayahuasca) is a prohibited psychotropic under Article 245 of the General Health Law. No regulated therapeutic pathway; some ceremonial/traditional tolerance exists but does not constitute lawful supervised-therapy access.
Official source (2026-06) ↗Mescaline / Peyote
IllegalMescaline and peyote are prohibited under Article 245 of the General Health Law. Indigenous/traditional ceremonial use (e.g. Huichol/Wixarika) is culturally protected, but there is no general lawful therapeutic pathway.
Official source (2026-06) ↗Ketamine
Legal / regulated accessTracked separately — a prescription medicine, excluded from the blended status.
Prescription anesthetic / off-label therapeutic use under medical supervision (COFEPRIS-regulated). Legal as a controlled medicine.
Official source (2026-06) ↗Educational information, not legal advice. Laws change — confirm with the official sources above before making decisions.
Looking for legal psychedelic-assisted therapy?
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