Is Psychedelic Therapy Legal in Colorado?
Colorado operates a regulated pathway to supervised therapeutic use of at least one psychedelic — one of the few US states to do so.
Status by substance
State-level status for lawful supervised therapeutic use. Regardless of state law, classic psychedelics remain Schedule I federally. Last reviewed 2026-06.
Psilocybin
Legal / regulated accessRegulated therapeutic access: Prop 122 / SB23-290 Natural Medicine program; state-licensed healing centers operating since 2025 (30+ licensed) where adults 21+ receive supervised psilocybin with a licensed facilitator. Personal possession also decriminalized.
Official source (2025-03) ↗MDMA
IllegalSchedule I; NOT included in Prop 122 natural-medicine list, no state therapeutic pathway.
Official source (2026-06) ↗Ibogaine
DecriminalizedProp 122 decriminalized personal use/possession for adults 21+; no regulated supply yet (psilocybin is first in the regulated program; ibogaine may be added to the program after 2026).
Official source (2026-06) ↗DMT / Ayahuasca
DecriminalizedDMT decriminalized for personal use/possession adults 21+ under Prop 122; no regulated therapeutic supply yet.
Official source (2026-06) ↗Mescaline / Peyote
DecriminalizedMescaline (excluding peyote) decriminalized for personal use adults 21+ under Prop 122; peyote excluded out of respect for Indigenous use; no regulated supply yet.
Official source (2026-06) ↗Ketamine
Legal / regulated accessTracked separately — a prescription medicine, excluded from the blended status.
Prescription / off-label clinic-based therapeutic use (Schedule III).
Official source (2026-06) ↗Educational information, not legal advice. Laws change — confirm with the official sources above before making decisions.
Looking for legal psychedelic-assisted therapy?
ATMA CENA provides supervised, legal psychedelic-assisted therapy in Canada and trains practitioners across North America.