Is Psychedelic Therapy Legal in the United States?

Federal: Schedule I under the Controlled Substances Act (no accepted medical use federally). Substantial state-level variation — Oregon and Colorado have regulated supervised-access programs; several cities have decriminalized. State nuance handled in the US-states layer.

Federal: Schedule I under the Controlled Substances Act. FDA rejected MDMA-assisted therapy approval (2024); access is clinical-trial / expanded-access only, which does not count as Legal. State variation tracked in the US-states layer.

Federal: Schedule I under the Controlled Substances Act. No federal therapeutic pathway. Some states (e.g. Texas) fund ibogaine research; state-level nuance in the US-states layer.

Federal: DMT is Schedule I under the Controlled Substances Act. Limited religious exemptions exist (UDV, Santo Daime) under RFRA, but a religious exemption alone does not create lawful supervised-therapy access.

Federal: mescaline and peyote are Schedule I under the Controlled Substances Act. A narrow exemption permits peyote use by members of the Native American Church.

Tracked separately — a prescription medicine, excluded from the blended status.

Schedule III prescription anesthetic; FDA-approved esketamine (Spravato) and widespread off-label ketamine therapy under medical supervision. Legal as a controlled medicine.